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대원제약, 엘베이스 NSCLC 신약 라이선스 계약 - 바이오스펙테이터

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대원제약, 엘베이스 NSCLC 신약 라이선스 계약

입력 2021-01-21 14:23 수정 2021-01-21 17:48

바이오스펙테이터 서윤석 기자

암세포서 자가포식 작용 억제 통해 항암제 내성 발생 억제기전 ‘LB217’..전임상 마치고 국내외 1/2상 준비 중

대원제약은 21일 엘베이스와 폐암 치료제의 라이선스 및 공동개발 계약을 체결했다고 밝혔다.

대원제약과 엘베이스가 공동개발하는 ‘LB-217’은 비소세포폐암(NSCLC) 표적치료제를 투여 받은 환자에게서 약물에 대한 내성 발생을 억제함으로써 항암 효과를 높이는 방식의 약물이다.

구체적으로, LB-217은 자가포식의 중요인자인 Beclin1과 CAGE(Cancer Associated GEne)의 결합을 억제해 암세포에서 과활성화된 자가포식 작용을 감소시켜 항암제에 대한 내성 발생을 지연시킨다. 대원제약에 따르면 폐암세포주에 LB-217을 투여하고 표적항암제인 오시머티닙, 엘로티닙을 적용했을 때, 암세포의 성장이 대조군 대비 유의미하게 억제된 결과를 확인했다는 설명이다

현재 LB217은 국내/외에서 임상 1상과 2상을 준비 중이다.

백승열 대원제약 부회장은 “폐암으로 고통받는 환자들에게 도움이 될 수 있도록 치료제 개발을 위해 노력할 것”이라고 말했다.

전도용 엘베이스 대표는 “암세포에서만 선택적으로 자가포식 작용을 억제할 수 있는 약물이 될 것으로 기대한다”고 말했다.

한편, 2019년 기준 국내 폐암 환자 수는 약 10만 명으로 추정되며, 이중 비소세포폐암 환자는 전체 폐암 환자의 약 80%를 차지하고 있다.

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