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다케다, 프레이저와 힐백스 설립.."노로virus 백신 개발" - 바이오스펙테이터

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다케다, 프레이저와 힐백스 설립.."노로virus 백신 개발"

입력 2021-08-04 08:08 수정 2021-08-04 08:08

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개발 및 일본외 지역 상업화 권리 부여..중등도에서 중증 급성 위장염 예방효율 61.8%

다케다 파마슈티컬(Takeda Pharmaceutical)은 지난달 29일(현지시간) 투자회사 프레이저 헬스케어 파트너스(Frazier Healthcare Partners)와 힐백스(HilleVax)를 공동 설립한다고 밝혔다. 힐백스는 다케다의 노로바이러스(norovirus) 백신 후보를 개발하고 상업화하기 위해 설립되는 바이오회사다. 힐백스의 대표는 프레이저의 벤처파트너 롭 허쉬버그(Rob Hershberg) 박사가 맡는다.

다케다는 힐백스에 노로바이러스 백신 후보물질 ‘HIL-214(TAK-214)’에 대한 개발 및 상업화 권리(일본 제외)를 부여한다. 일본 내에서는 다케다가 상업화 권리를 유지한다. 다케다는 힐백스로부터 계약금, 마일스톤, 판매 로열티를 받게 되나 구체적 금액은 공개되지 않았다.

HIL-214는 다케다가 개발을 진행해왔던 노로바이러스 GI.1/GII.4 바이러스 유사입자(virus-like particle, VLP) 기반 2가 백신 후보다. VLP란 바이러스와 유사한 외피를 가져 면역반응은 유도할 수 있으나 유전물질이 없어 감염 증세는 나타나지 않는 물질이다. 다케다는 현재 노로바이러스 감염에 허가된 백신은 없으며 HIL-214가 임상에서 가장 앞서 있다고 설명했다.

다케다는 지난 2020년 논문을 통해 HIL-214의 임상2b상의 결과를 발표했다(doi: 10.1016/j.vaccine.2020.07.069). 다케다는 4712명의 건강한 참여자를 대상으로 한 임상 결과에서 HIL-214가 전체 노로바이러스 유전형에서 중등도에서 중증(moderate-to-severe) 급성 위장염(acute gastroenteritis)에 대해 위약대비 61.8%의 예방효율(vaccine efficacy)을 보이는 것을 확인했다(95.01% CI: 20.8~81.6%, p=0.0097).

라지브 벤카야(Rajeev Venkayya) 다케다 국제 백신사업부 사장은 “우리는 노로바이러스 관련 급성 위장염의 전세계적 큰 부담을 해결할 가능성을 가진 HIL-214에 대한 힐백스의 개발 능력을 확신한다”며 “이를 통해 타케다가 노력과 자원을 올해 허가서류를 제출할 댕기열 백신, 팬데믹 프로그램, 지카 바이러스 백신 개발을 위한 미국 정부와의 파트너십에 집중할 수 있게될 것”이라고 말했다.

타치 야마다(Tachi Yamada) 힐백스 공동설립자 겸 프레이저의 벤처 파트너는 “노로바이러스는 전세계적으로 경제적, 사회적 비용뿐만아니라 발병률과 사망률을 발생시키고 있다. 우리는 HIL-214가 이같은 미충족 수요를 해결할 중요한 기회를 보여줄 것으로 믿는다”고 말했다.

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