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크리스탈 "췌장암 후보물질 동물실험서 가능성 확인" - 바이오스펙테이터

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크리스탈 "췌장암 후보물질 동물실험서 가능성 확인"

입력 2017-02-01 18:35 수정 2018-01-08 13:47

바이오스펙테이터 박준범 기자

이 기사는 '프리미엄 뉴스서비스 BioS+' 기사입니다.
사이언티픽리포트에 비임상연구논문 게재..'기존치료제와 병용투여시 효과'

크리스탈지노믹스가 연구중인 췌장암치료 후보물질이 동물실험에서 가능성을 확인했다는 내용의 논문이 국제학술지에 발표됐다.

크리스탈은 송시영 세브란스병원 교수팀과 공동연구 중인 췌장암 분자표적항암제(CG200745)의 비임상 연구 논문을 사이언티픽 리포트(Scientific Reports)에 지난 1월30일자로 게재했다고 1일 밝혔다.

CG200745는 HDAC(Histone deacetylation) 저해제로 후성유전학 유래 항암제다. 후성유전학이란 유전자의 발현 조절 기전을 연구하는 학문이다. 크리스탈은 CG200745에 대해 식품의약품안전처로부터 개발단계 희귀의약품으로 지정 받고 골수형성이상증후군(MDS) 적응증으로 임상 1b/2상 진행 중이다.

연구에서는 췌장암 환자에게 처방되는 화학요법인 젬시타빈, 엘로티닙에 CG200745를 병용투여 했을 때 효능 향상 정도와 내성 발생 환자에 대한 효과 여부를 관찰했다.

▲췌장암 종양 크기, 무게 변화(크리스탈지노믹스)...

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