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348 Warning: mysql_real_escape_string(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_real_escape_string(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_query(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 530 Warning: mysql_query(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 530 Warning: mysql_fetch_array() expects parameter 1 to be resource, boolean given in /service/web/biospcmbl/comlib/dblib.php on line 531 툴젠 CAR-T 'Styx-T', 면역억제환경 극복 가능성 확인 - 바이오스펙테이터

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툴젠 CAR-T 'Styx-T', 면역억제환경 극복 가능성 확인

입력 2018-07-04 13:36 수정 2018-07-05 06:26

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이 기사는 유료회원만 이용할 수 있는 BioS+ 기사입니다.
Cancer Research 저널 온라인판에 게재.."DGK 제거 CAR-T, 뇌종양 마우스 모델서 in vivo 효능 확인".."PD-1 제거 CAR-T보다 효능 ↑"

툴젠이 CRISPR/Cas9 기술 적용 CAR-T 플랫폼기술 ‘Styx-T'로 면역억제환경을 극복함으로써 고형암 치료에 적용할 수 있는 가능성을 제시했다.

툴젠 연구팀은 CRISPR 기술로 T세포 활성을 저해하는 DGK 유전자를 제거한 CAR-T세포에서 면역억제인자가 존재하거나 T세포가 제 기능을 못하는 무반응(T cell anergy) 상황에서도 항암효과를 관찰했다. 특히 주목할 부분은 뇌종양 쥐 모델에서 억제성 면역관문인 PD-1 제거 CAR-T 보다 우수한 효능을 보였다는 점이다. DGK 제거 CAR-T가 고형암의 면역억제 환경을 극복할 새로운 접근법을 제시한 셈이다.

이정민 툴젠 연구소장은 “이번 연구를 통해 툴젠의 플랫폼기술 'Styx-T'를 적용한 CAR-T로 뇌종양 동물모델에서 고형암 치료 가능성을 확인했다. 앞으로 혈액암, 흑색종 등 다양한 암 유형에서 DGK 제거 CAR-T의 효능을 확인할 예정이다”면서 “플랫폼 기술이전 또는 파트너사와 공동연구 등 상황에 따라 유연한 비즈니스 전략을 제시하겠다”고 말했다.

이번 연구결과는 ‘CRISPR/Cas9-mediated knockout of DGK improves anti-tumor activities of human T cells’ 제목으로 지난 2일 Cancer Research 저널 온라인판에 공개됐다.

◇ 새 타깃, DGK 유전자 주목한 이유

현재 CAR-T치료제(Chimeric Antigen Receptor-T)는 혈액암에서 높은 완치율을 보이며 획기적인 치료제로 인정받고 있으나 전체 암환자의 80~90%에 해당하는 고형암에서는 CAR-T의 효능에 한계를 보이고 있다. 이를 극복하기 위해 종양미세환경을 극복하는 차세대 CAR-T 개발이 새로운 트렌드다....

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