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GC녹십자, 혈우병 'TFPI 항체' 치료제 "임상1상 시작" - 바이오스펙테이터

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GC녹십자, 혈우병 'TFPI 항체' 치료제 "임상1상 시작"

입력 2019-02-28 10:40 수정 2019-02-28 10:40

바이오스펙테이터 김성민 기자

MG1113 혈액응고 저해기능 낮추는 TFPI 항체로 기존 치료제 내성 보이는 혈우병 환자 및 혈우병A형, B형에 모두 적용 가능할 것

GC녹십자가 자체 기술로 개발한 혈우병 항체치료제 ‘MG1113’ 임상 1상에서 첫 환자 투여를 시작했다고 28일 밝혔다. 혈우병은 혈액 내 응고인자 기능이상으로 피가 잘 멈추지 않는 질환이다.

이번 임상시험은 연세대 세브란스병원과 고려대 안암병원에서 건강한 성인과 혈우병 환우 49명을 대상으로 MG1113을 투여해 안전성을 평가한다.

MG1113은 조직인자계 응고억제제(tissue factor pathway inhibitor, TFPI)를 저해하는 항체다. MG1113은 부족한 혈액 내 응고인자(Factor IX, Factor VIII)를 주입하는 기존 치료 방식과 달리 응고인자들을 활성화시키는 항체로 만들어진 혈우병 항체치료제 파이프라인이다.

GC녹십자는 기존 약에 내성이 생긴 환자도 사용이 가능하며, A형과 B형 혈우병에도 모두 사용할 수 있을 것으로 기대하고 있다. 또한 MG1113은 기존 약보다 반감기가 긴 고농도 제형으로 피하주사가 가능해 약물 투여 횟수를 줄여 환자 편의성이 높아질 것으로 기대한다.

김진 GC녹십자 의학본부장은 “‘MG1113’은 GC녹십자의 희귀질환 치료제 개발 기술력의 집합체”라며 “이번 연구를 통해 치료 효과를 확인한 후 상업화를 위한 후속 연구에 더욱 박차를 가할 계획”이라고 말했다.

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