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레고켐, 美 밀레니엄에 ADC플랫폼 4억弗 기술이전 - 바이오스펙테이터

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레고켐, 美 밀레니엄에 ADC플랫폼 4억弗 기술이전

입력 2019-03-22 10:28 수정 2019-03-22 14:20

바이오스펙테이터 장종원 기자

선급금 및 단기마일스톤 725만달러..밀레니엄, 3가지 타깃 대상 ADC 면역항암 후보물질 발굴

레고켐바이오가 항체-약물접합(ADC) 플랫폼 기술을 다케다 자회사인 밀레니엄 파마슈티컬에 기술이전했다. 총 규모가 4억달러(약 4500억원)에 이르는 대형 기술이전 계약이다.

레고켐 바이오사이언스는 22일 ADC원천기술인 'ConjuALL'을 미국 밀레니엄 파마슈티컬에 기술이전했다고 밝혔다.

이번 계약으로 레고켐바이오는 선급금 및 단기 마일스톤 725만달러(약 80억원)과 개발 및 허가에 따른 마일스톤 3억9675만달러를 포함 총 4억400만달러의 기술료를 지급받게 된다. 이와 별도로 매출액에 따른 로열티를 추가적으로 수령하게 된다.

밀레니엄은 ADC선두기업인 다케다의 100% 자회사로서 항암제 분야에 특화된 연구개발능력을 보유한 회사다. 다케다는 이미 시판중인 ADC블록버스터 제품 '애드세트리스(Adcetris)'의 허가승인과 성공적인 사업화 경험을 보유하고 있으며 다양한 2세대 ADC기술을 평가해온 제약회사로 잘 알려져 있다.

ADC는 항암효과가 뛰어난 항암약물을 타깃 치료제인 항체의약품과 접합해 강력한 효능의 항암약물이 암세포에만 작용하도록 하는 기술이다. 레고켐의 ConjuALL은 위치 특이적 결합방법(Site-Specific Conjugation)으로 혈중안정성을 개선한 링커를 기반으로 하는 차세대 ADC 플랫폼 기술이다.

밀레니엄은 레고켐바이오의 ADC플랫폼을 활용해 3가지 타깃을 대상으로 면역항암 후보물질 발굴할 예정이며 추후 발굴한 후보물질의 글로벌시장 대상 개발 및 상업화에 대한 독점권을 갖게 된다.

레고켐바이오의 김용주 대표이사는 "이번 계약으로 당사의 ADC기술이 글로벌 제약사로부터 다양한 타깃으로 개발이 가능한 확장성, 그리고 상업화가 가능한 플랫폼 기술로 인정받는 계기가 됐다"면서 "이번 계약을 시작으로 링커 그리고 톡신 플랫폼기술을 활용한 다양한 파이프라인의 글로벌 사업화를 성공시켜 글로벌 ADC시장에서 레고켐바이오의 경쟁력을 입증하겠다"라고 말했다.

레고켐바이오는 이번 다케다 기술이전을 시작으로 고유 링커, 톡신 플랫폼기술과 다수의 ADC치료제 파이프라인을 대한 향후 추가적인 글로벌 기술이전이 기대하고 있다. 또한, 국내 임상2상 및 호주 임상 1상이 진행중인 항생제 그리고 파트너사를 통해 미국 임상 1상이 진행중인 항섬유화제 등 합성신약분야에서도 개발 속도를 높인다는 계획이다.

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