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마크로젠, 교모세포종 '암 줄기세포 마커' 국내 특허 - 바이오스펙테이터

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마크로젠, 교모세포종 '암 줄기세포 마커' 국내 특허

입력 2020-02-17 11:04 수정 2020-02-17 11:04

바이오스펙테이터 장종원 기자

암 줄기세포 분석해 다수의 유전자 바이오마커 발굴..국내외 주요 제약사와 업무협력 추진

마크로젠은 악성 뇌종양인 ‘교모세포종 암 줄기세포 바이오마커’와 관련해 국내 특허를 취득했다고 17일 밝혔다.

이번 특허는 교모세포종 암 줄기세포에서 특이적으로 나타나는 다수의 유전자를 검출하고, 이를 암 진단 마커의 용도 및 항암제∙억제제 스크리닝을 위한 용도로 제시하는 기술이다. 특허명은 ‘암 줄기세포 특이적 바이오마커’다.

마크로젠 연구팀은 우선 암 줄기세포를 생성하기 위해 특정 조건에서 교모세포종 세포를 배양했다. 배양된 교모세포종 세포에서 줄기세포 마커인 SOX2가 발현됐으며 이를 통해 연구팀은 교모세포종 세포가 암 줄기세포로 변환됐음을 확인했다.

이렇게 생성된 암 줄기세포를 마이크로어레이(Microarray) 방식으로 분석한 결과, 교모세포종 암 줄기세포의 존재를 예측할 수 있는 다수의 새로운 바이오마커를 발굴했다. 바이오마커는 C16ofr45, NHS, GSN, ZFAND5, SSBP2, SH3BP4, SIPA1L1, PALLD, ZFAND5, MIR542, MIR1977, MIR663, MIR891B 등 유전자다.

최근 암 줄기세포가 뇌종양 세포의 침윤과 저항성의 원인으로 지목되면서 관련 연구가 활발히 이루어지고 있지만, 실제 몸속에서 자라는 종양 내부는 매우 이질적이고 다양한 세포 집합으로 이루어져 있어 종양의 근원세포인 암 줄기세포만을 찾아내기가 매우 어렵고 높은 기술력을 필요로 한다. 이에 암 줄기세포의 존재를 확인할 수 있는 바이오마커 발견의 필요성이 지속적으로 대두돼 왔다.

양갑석 마크로젠 대표는 "이번 특허를 기반으로 향후 암 줄기세포의 선택적 치료제 및 억제제 개발 사업을 위해 다국적 제약사와의 업무협력을 적극적으로 추진할 계획이다"라고 밝혔다.

▲마크로젠은 교모세포종 암 줄기세포(빨간색 부분)의 존재를 예측할 수 있는 다수의 새로운 바이오마커를 발굴했다. 바이오마커는 C16ofr45, NHS, GSN, ZFAND5, SSBP2, SH3BP4, SIPA1L1, PALLD, ZFAND5, MIR542, MIR1977, MIR663, MIR891B 등 유전자다.

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