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갈라파고스, 'SIK저해제' "안전성 확인, 효능 기대못미쳐" - 바이오스펙테이터

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갈라파고스, 'SIK저해제' "안전성 확인, 효능 기대못미쳐"

입력 2021-07-19 06:40 수정 2021-07-19 11:02

바이오스펙테이터 윤소영 기자

이 기사는 '프리미엄 뉴스서비스 BioS+' 기사입니다.
SIK(Salt Inducible Kinase) 저해제 'GLPG3970', 염증성질환 치료제 개발위한 톨레도(Toledo)프로그램의 리드파이프라인

갈라파고스(Galapagos)가 집중 개발하고 있는 파이프라인 SIK 저해제 ‘GLPG3970’의 염증성 질환 대상 임상결과가 공개됐다. 임상 결과 건선(Psoriasis), 궤양성대장염(Ulcerative Colitis, UC), 류마티스 관절염(Rheumatoid Arthritis, RA) 등 3개 임상에서 GLPG3970의 안전성 및 내약성을 모두 확인됐다. 하지만 궤양성대장염 및 류마티스 관절염 임상에서 GLPG3970은 위약군 대비 효능 차이를 보여주지 못하며 기대에 미치지못하는 결과를 냈다.

갈라파고스는 지난 14일 SIK(Salt Inducible Kinase)2/3 저해제 ‘GLPG3970’으로 진행한 3개의 염증성질환 임상 결과를 발표했다. 하나는 중등도~중증 건선 환자를 대상으로 한 임상 1b상, 나머지 두개는 중등도~중증의 궤양성대장염과 류마티스 관절염 임상 2a상이었다.

발표에 따르면 3개의 임상에 참여한 환자들은 6주동안 GLPG3970 혹은 위약을 경구로 하루 1번 복용했다. 이번 임상에서 갈라파고스는 GLPG3970의 안전성 및 내약성, 효능 등을 평가했으며 모든 임상에서 GLPG3970은 좋은 안전성 및 내약성을 보여줬다.

효능과 관련해 먼저 건선 임상을 살펴보면, 임상에는 총 26명의 환자가 참가했으며 이중 15명이 GLPG3970을 투약받았다(NCT04106297). 이중 2명은 코로나19감염과 가려움증으로 치료를 중단해 임상 결과는 13명의 환자를 대상으로 분석했다....

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