TiCARos, Development of CTLA4 gene modificated CAR-T to avoid immune tolerance
입력 2018-08-29 08:03 수정 2018-09-20 09:08
by Euna Lee
TiCARos is a new bio-startup founded in June 2018 by President Lee Jae-won, whose career had been in a foreign bank, and Professor Choi Gyeong-soo of Seoul National University, who, when he was working in the National Cancer Center, was a developer of the original technology.
President Lee Jae-won of TiCARos explained, “TiCARos focuses on reinforcement of the anti-cancer function of T-cell. Existing cancer-specific T-cell therapy has employed an injection of proliferated cells, whereas the CAR-T cell resulted from genetic manipulation manifested limitations in therapeutic efficacy for solid cancer. We have introduced the CTLA4 gene, which was manipulated to activate T-cell and cancer antigen target CAR simultaneously for the development of ‘CAR-CTC28 double gene T-cell’, which enabled the reduction of side effects, and a strong anticancer effect to be attained”
◇ Reinforced CAR-T, “Cancer Antigen Target + ‘T-Cell Tolerance Brake’ Simultaneously”
TiCARos focuses on the prevention of cancer-specific T-Cell tolerance to overcome the limitations of existing immunotherapeutic agents. TiCARos is also developing ‘CAR-CTC28 T-cell’, the next-generation CAR-T cell that promotes anti-cancer functions. It is the simultaneous introduction of Chimera Antigen Receptor (CAR) and CTLA4-CD28 Chimera (CTC28), which is a manipulation of CTLA4 gene to activate T-cell, into T-cell. It was designed to work selectively on cancer-specific T-cell to reduce side effects, and to promote therapeutic efficacy.
Professor Choi Gyeong-ho, who developed the core technology of TiCARos, explained, “the ‘T-cell tolerance’ that deactivates T-cell should be prevented to make the T-cell stronger. For this, TiCARos has introduced CAR and CTC28 to T-cell. CAR targets specific cancer antigen, while CTC28 blocks the CTLA4-B7 channel of suppression signal transference, and simultaneously activates the CD28-B7 channel for activation signal transference that maximizes the anti-cancer function of cancer-specific T-cell”...