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GC녹십자, 'TFPI 타깃 혈우병신약' 비임상 결과는 - 바이오스펙테이터

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GC녹십자, 'TFPI 타깃 혈우병신약' 비임상 결과는

입력 2020-05-26 09:17 수정 2020-05-26 10:56

바이오스펙테이터 봉나은 기자

이 기사는 '프리미엄 뉴스서비스 BioS+' 기사입니다.
MG1113, 중화항체로 인해 약물 효력 감소현상 보이는 in vivo 모델서 출혈량 감소 확인..주1회 IV·SC제형 적용 가능.."내년 글로벌 임상2상 진입 목표“

GC녹십자가 임상 1상을 진행중인 혈우병 치료 항체 ‘MG1113’의 비임상 데이터를 공개했다. MG1113은 환자에게 결핍된 혈액응고인자를 정맥주사로 주 3회 투여해야 하는 기존 혈우병 치료제의 치료 방식을 개선하고, 치료 약물에 대한 항체(ADA)가 형성됨에 따라 발생할 수 있는 부작용을 최소화하도록 설계된 약물이다.

김민정 GC녹십자 정제2팀 팀장은 지난 18일 온라인으로 진행된 '바이오코리아 2020' e-컨퍼런스의 항체 세션에서 '최신 기술을 적용한 혈우병 치료항체 개발'에 대해 발표했다. 김 팀장은 “MG1113을 정맥주사(IV) 및 피하주사제(SC)로 개발해 약물 효능 확인했다”면서, “이러한 비임상 데이터를 바탕으로 현재 혈우병 환자 대상 임상1상을 진행하고 있으며 내년 글로벌 임상2상에 진입할 계획”이라고 말했다.

TFPI 타깃 혈우병 치료항체 ‘MG1113’

혈액응고기작은 내인성과 외인성 기전으로 나뉘며 둘 중 하나의 기전만 활성화돼도 트롬빈과 피브린을 생성해 혈액응고를 유도할 수 있다....

'프리미엄 뉴스서비스 BioS+'는 독자들에게 가치(value)있는 기사를 제공합니다.
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