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348 Warning: mysql_real_escape_string(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_real_escape_string(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_query(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 530 Warning: mysql_query(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 530 Warning: mysql_fetch_array() expects parameter 1 to be resource, boolean given in /service/web/biospcmbl/comlib/dblib.php on line 531 유한양행 3세대 EGFR TKI '레이저티닙', 최신 임상결과는? - 바이오스펙테이터

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유한양행 3세대 EGFR TKI '레이저티닙', 최신 임상결과는?

입력 2018-09-27 12:08 수정 2018-09-28 13:07

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세계폐암학회(WCLC)서 발표.."DCR 89%, 전체반응률(ORR) 61%, T790M 변이 환자 ORR 66%, 뇌전이 발생 환자 ORR 50%"

유한양행과 제노스코가 공동 개발 중인 레이저티닙(Lazertinib, YH25448/GNS-1480)의 업데이트된 임상1/2상 결과가 26일(현지시간) 세계폐암학회(WCLC 2018)에서 공개됐다. 레이저티닙은 EGFR T790M 변이를 가진 비소세포폐암 환자에서 66%의 높은 반응률과 안전성을 보이며 ‘Best-in-Class' 치료제로서의 가능성을 보였다.

레이저티닙은 EGFR 변이(Del19, L858R) 및 T790M 저항성 변이에 높은 선택성을 갖는 경구형 3세대 타이로신 인산화효소 억제제(Tyrosine kinase inhibitor, TKI)다. 특히 뇌혈관장벽(BBB)를 통과할 수 있어 뇌전이가 발생한 폐암환자에서도 우수한 효능이 기대되고 있다.

학회 구두발표에 나선 임상연구 책임자인 조병철 연세대 교수는 “발표 후 토론자로 나온 피츠버그 의대 Liza Villaruz 교수 평에 따르면 적어도 타그리소 보다 나은 효능과 적은 독성이 크게 예상된다고 언급했다”고 전했다.

▲조병철 연세대 종양학과 교수가 26일(현지시간) 캐나다 토론토에서 열린 ‘제19회 세계폐암학회(WCLC)’에서 레이저티닙(Lazertinib)의 업데이트된 임상결과를 발표하고 있다.

이번에 발표한 임상1/2상 연구(NCT03046992)는 뇌전이(BM) 유무와 관계없이 EGFR-TKI로 치료 후 저항성을 가진 진행성·전이성 비소세포폐암 환자를 대상으로 오픈라벨, 다기관 용량증량, 용량 확대 코호트로 진행했다. 용량 증량 코호트에 환자 38명, 용량 확대 코호트에 77명이 포함돼 총 115명 환자가 참여했다....

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