Warning: mysql_real_escape_string(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_real_escape_string(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_query(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 346 Warning: mysql_query(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 346 Warning: mysql_num_rows() expects parameter 1 to be resource, boolean given in /service/web/biospcmbl/comlib/dblib.php on line 348 Warning: mysql_real_escape_string(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_real_escape_string(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_query(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 346 Warning: mysql_query(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 346 Warning: mysql_num_rows() expects parameter 1 to be resource, boolean given in /service/web/biospcmbl/comlib/dblib.php on line 348 Warning: mysql_real_escape_string(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_real_escape_string(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_query(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 346 Warning: mysql_query(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 346 Warning: mysql_num_rows() expects parameter 1 to be resource, boolean given in /service/web/biospcmbl/comlib/dblib.php on line 348 Warning: mysql_real_escape_string(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_real_escape_string(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_query(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 346 Warning: mysql_query(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 346 Warning: mysql_num_rows() expects parameter 1 to be resource, boolean given in /service/web/biospcmbl/comlib/dblib.php on line 348 Warning: mysql_real_escape_string(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_real_escape_string(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_query(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 346 Warning: mysql_query(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 346 Warning: mysql_num_rows() expects parameter 1 to be resource, boolean given in /service/web/biospcmbl/comlib/dblib.php on line 348 Warning: mysql_real_escape_string(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_real_escape_string(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_query(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 346 Warning: mysql_query(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 346 Warning: mysql_num_rows() expects parameter 1 to be resource, boolean given in /service/web/biospcmbl/comlib/dblib.php on line 348 Warning: mysql_real_escape_string(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_real_escape_string(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_query(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 346 Warning: mysql_query(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 346 Warning: mysql_num_rows() expects parameter 1 to be resource, boolean given in /service/web/biospcmbl/comlib/dblib.php on line 348 Warning: mysql_real_escape_string(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_real_escape_string(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_query(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 346 Warning: mysql_query(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 346 Warning: mysql_num_rows() expects parameter 1 to be resource, boolean given in /service/web/biospcmbl/comlib/dblib.php on line 348 Warning: mysql_real_escape_string(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_real_escape_string(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_query(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 346 Warning: mysql_query(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 346 Warning: mysql_num_rows() expects parameter 1 to be resource, boolean given in /service/web/biospcmbl/comlib/dblib.php on line 348 Warning: mysql_real_escape_string(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_real_escape_string(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_query(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 346 Warning: mysql_query(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 346 Warning: mysql_num_rows() expects parameter 1 to be resource, boolean given in /service/web/biospcmbl/comlib/dblib.php on line 348 Warning: mysql_real_escape_string(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_real_escape_string(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 30 Warning: mysql_query(): Access denied for user 'et1ssh96'@'localhost' (using password: NO) in /service/web/biospcmbl/comlib/dblib.php on line 530 Warning: mysql_query(): A link to the server could not be established in /service/web/biospcmbl/comlib/dblib.php on line 530 Warning: mysql_fetch_array() expects parameter 1 to be resource, boolean given in /service/web/biospcmbl/comlib/dblib.php on line 531 CAR-T 진화한 CAR-Treg, 면역·염증질환 ‘블루오션’ 타깃 - 바이오스펙테이터

본문 바로가기

바이오스펙테이터

기사본문

CAR-T 진화한 CAR-Treg, 면역·염증질환 ‘블루오션’ 타깃

입력 2017-07-10 09:29 수정 2017-07-18 07:11

바이오스펙테이터 이은아 기자

이 기사는 유료회원만 이용할 수 있는 BioS+ 기사입니다.
프랑스 'TxCell' 크론병, 이식편대숙주 질환에서 ‘항원 특이적 Treg’ 치료제로 첫 POC 증명

면역관련 질환에 도전하는 새로운 'CAR(키메라 항원 수용체)-T' 치료제가 등장했다. 프랑스 바이오텍 TxCell이 개발하는 CAR-Treg(T regulatory Cells)가 그 주인공이다. TxCell은 CAR-Treg 세포를 이용해 항암제가 아닌 크론병, 루푸스신염, 다발성경화증, 장기이식 거부반응 등 다양한 자가면역질환, 염증질환 치료를 목표로 한다.

TxCell은 항원 특이적 조절 T세포(T regulatory Cells, Treg) 기반 치료제로 임상 단계까지 진입한 유일한 회사이다. ‘타깃 세포, 치료기전, 타깃 질환‘ 등 모든 부분에서 독점적인 포지션을 차지하는 ’퍼스트무버‘인 셈이다.

노바티스, 카이트파마, 주노 테라퓨틱 등이 개발하고 있는 기존의 CAR-T 치료제가 ‘작용 T세포(T effector cells)’에 키메릭 항원 수용체(CAR)를 도입해 면역체계를 ‘활성화’(Stimulate)시켜 ‘암’을 공격하는 전략이라면, TxCell의 CAR-Treg 치료제는 ‘조절 T세포’를 변형해 비정상으로 활성화 되어있는 환자의 면역체계를 ‘조절’(Control)해 ‘면역질환’을 치료하려는 계획이다.

TxCell는 2001년 프랑스 연구기관인 INSERM(Institut National de la Santé et de la Recherche Médicale)에서 스핀아웃해 설립된 회사다. CAR-T 치료제 창시자인 젤리그 에사(Zelig Eshar) 박사를 포함한 세계적인 면역학 전문가들로 과학자문위원회(Scientific Advisory Board)가 구성되어있다. 지난해 10월에는 전 노바티스 CAR-T 프로젝트 연구책임자인 Li Zhou 박사가 셀 엔지니어링 파트로 영입됐다.

면역 항상성 유지하는 Treg 세포치료제, Treg 전문회사 약 9000억 원에 인수합병

조절 T세포(이하 Treg)에 기반을 둔 TxCell은 두 가지 플랫폼 기술을 보유하고 있다. 크론병 치료제로 임상2상 진행 중인 자연 항원 특이적 Treg(Ag-Treg)의 ‘ASTrIA’ 플랫폼 기술과 장기이식 거부반응 치료제로 비임상 시험 중인 CAR-Treg의 ‘ENTrIA’ 플랫폼 기술이다.

면역을 활성화시켜 외부의 침입자나 암세포를 직간접적으로 공격하면서 우리 몸을 보호하는 효과 T세포와 달리, Treg는 면역반응을 적절하게 조절하여 면역체계의 항상성을 유지한다. 즉, 외부침입자를 공격한 후에도 계속 면역반응이 활성화되거나 면역체계가 이상을 일으켜 오히려 자신의 인체를 공격하는 자가면역 현상을 일으키는 경우 면역을 억제하는 역할을 한다.

다른 세포에 비해 상대적으로 최근인 1995년 Sakagushi 박사에 의해 발견된 Treg는 이후 만성 대장염 마우스 동물모델에서 항염증 특성을 확인하면서 자가면역질환이나 장기이식 거부를 치료하는데 잠재성이 클 것으로 기대됐다.

2000년대 초 이후에는 Treg(FoxP3 양성) 기반 치료 접근법...

이 기사는 유료회원만 이용할 수 있는 BioS+ 기사입니다.
유료회원이시면 로그인 해주시고, 유료회원가입을 원하시면 클릭 해주세요.
카카오스토리로 기사 공유하기 댓글영역으로 이동