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종근당 "류마티스관절염 신약 유럽 2a상 2020년 완료" - 바이오스펙테이터

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종근당 "류마티스관절염 신약 유럽 2a상 2020년 완료"

입력 2019-03-14 13:32 수정 2019-03-14 13:32

바이오스펙테이터 장종원 기자

HDAC6 억제 기전 자가면역질환 신약, 범부처신약개발사업단 과제 선정

▲종근당은 14일 범부처신약개발사업단과 CKD-506의 연구개발 협약식을 가졌다. 범부처신약개발사업단 김성천 연구개발본부장(왼쪽 두번째부터), 종근당 김기원 의학실장, 범부처신약개발사업단 묵현상 단장, 종근당 김성곤 효종연구소장. 종근당 제공.

종근당이 개발하는 자가면역질환 치료제 'CKD-506'의 유럽 임상 2a상이 범부처신약개발사업단의 지원과제로 선정됐다.

종근당은 14일 범부처신약개발사업단과 CKD-506의 연구개발 협약을 체결했다. 종근당은 이번 협약으로 범부처신약개발사업단으로부터 류마티스관절염으로 적응증으로 하는 CKD-506의 유럽 임상 2a상 연구지원을 받게 됐다.

CKD-506은 다양한 염증성 질환에 영향을 미치는 히스톤디아세틸라제6(HDAC6)를 억제해 염증을 감소시키고, 면역 억제 T 세포의 기능을 강화해 면역 항상성을 유지시키는 새로운 작용기전의 치료제다.

종근당은 전임상 시험에서 CKD-506의 류마티스 관절염 치료 신약으로서의 개발 가능성을 확인했으며 2018년 유럽 임상 1상에서 안전성과 내약성, 약동학적 특성을 확인했다. 현재 류마티스 관절염 환자를 대상으로 유럽 5개국에서 임상 2a상을 진행 중이며, 2020년 완료할 계획이다.

종근당 관계자는 "CKD-506은 약물의 우수성과 개발 가능성을 인정받아 전임상 시험부터 범부처신약개발사업단의 지원과제로 선정됐다"면서 "기존 치료제를 대체할 수 있는 혁신 신약으로 개발해 글로벌 시장에 진출할 계획"이라고 말했다.

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